Commercial For Sale near Mississippi River

Discover a rare downtown La Crosse opportunity at 422-424 Main St. Formerly ''The Main'' event venue, this property blends historic character with modern versatility--featuring a large stage, lighting, bar, kitchen equipment, and a corner office suite. The expansive lower level offers ideal storage or additional build-out potential. The upper level at 424 Main is a luxury apartment currently used as a short-term rental, providing proven income. Keep the event use or reimagine the space for your vision--steps from restaurants, nightlife, and the riverfront. A flexible commercial property in the heart of downtown energy. All equipment is negotiable for a seamless transition. We'll help you shape the vision.

Property Details

  • Beds: 0
  • Baths: 0.0
  • Sq Feet: 7400
  • Year Built: 1900
  • Location: Mississippi River
  • Acres: 0.140
  • County: La Crosse County
  • Heat/AC: Natural Gas
  • Siding: Brick
  • Roof: Rubber
  • Stories: 2
  • Property Taxes: $12,914
  • MLS #: 1944606
  • Unit Number: 424

Location

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Contact Information:

Contact Agent
Joshua Genz
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United Country Midwest Lifestyle Properties
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Ad Statistics:

Lake Commercial For Sale in La Crosse, Wisconsin
Ad Number : 7362937
Viewed: 6 times
Added: Feb 10, 2026
Updated on: Feb 10, 2026
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